Synthesis of Hirtellanine B,an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells |
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| Authors: | Shuyan Zheng Runzhong Fu Zhengwu Shen |
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| Institution: | 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2. Departmen of Applied Chemistry, East China University of Sciences and Technology, Shanghai 20000, China;3. Basilea Pharmaceutica China Ltd., Haimen, Jiangsu 226100, China |
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| Abstract: | We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activity of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells. |
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| Keywords: | hirtellanine B synthesis antiproliferation G2/M arrest cancer cell |
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