聚二甲基硅氧烷基质微流控芯片通道的氧气氛改性研究

通过将新制的PDMS微流控芯片置于氧气氛中对通道表面进行处理的简单方法，使电渗流大小及稳定性有了显著的改善。同时研究了氧气处理PDMS通道表面的时间对电渗流的影响，得到氧气处理的最佳时间为3d。讨论了氧气作用于PDMS芯片表面的机理。在氧气处理3d的PDMS微流控芯片上进行氨基酸分离实验，得到较好的分离效果。

Surface Modification of Poly(dimethylsiloxane) Microfluidic Chips by Treatment in an Oxygen Atmosphere

Due to the inertness and hydrophobicity of polydimethyl silicone (PDMS) materials, surface ~modification is usually required prior to the use of PDMS microfluidic chips, to enhance its surface polarity, and also to stabilize electroosmosis. In this paper, a simple method was developed to enhance and stabilize electroosmotic flow of PDMS microfluidic chips, by placing the newly fabricated PDMS chips in an oxygen ~atmosphere . The effect of treatment time in O_2 atmosphere on electroosmotic flow of PDMS microfluidic chips has been tested. It showed that the most appropriate treatment time in O_2 atmosphere was 3 days. The mechanism of the PDMS surface modification in oxygen atmosphere was discussed in detail. The performance of the treated chips was demonstrated by the capillary electrophoresis (CE) separation of a mixture of two amino acids using PDMS microfluidic chips treated in O_2 atmosphere for 3 days. High separation efficiency and good reproducibility have been achieved.