| 对称四甲基取代六元瓜环对醋酸地塞米松的增溶作用 |
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| 引用本文： | 李国平,俞芳琴,林金鹤,陈银枝.对称四甲基取代六元瓜环对醋酸地塞米松的增溶作用[J].应用化学,2010,27(5):563-566. |
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| 作者姓名： | 李国平 俞芳琴 林金鹤 陈银枝 |
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| 作者单位： | (漳州师范学院化学与环境科学系 漳州 363000) |
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| 基金项目： | 教育厅科技项目，校教师科研启动经费资助项目 |
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| 摘 要： | 利用微孔滤膜分离方法研究了对称四甲基取代六元瓜环(TMeQ6])对醋酸地塞米松的增溶作用,并利用差热分析法(DTA)分析TMeQ6]和醋酸地塞米松的包结物。结果表明,TMeQ6]对醋酸地塞米松有一定的增溶作用,随TMeQ6]浓度增大,醋酸地塞米松的溶解度呈增大趋势,当TMeQ6]浓度从0.04mmol/L提高至0.28mmol/L增溶倍数可达4～17倍;当温度从10℃升至70℃,增溶倍数先下降然后趋于稳定。同时,还利用共溶剂法制备了TMeQ6]与醋酸地塞米松的固体包结物,并对其主客体作用进行了DTA研究。
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| 关 键 词： | 对称四甲基取代六元瓜 醋酸地塞米松 增溶 包结物 |
| 收稿时间： | 2009-07-09 |
| 修稿时间： | 2009-09-21 |
Solubility Improvement of Dexamethasone Acetate by Tetramethyl Substituted Cucurbit[6] uril |
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| LI Guo-Ping,YU Fang-Qin,LIN Jin-He,CHEN Yin-Zhi.Solubility Improvement of Dexamethasone Acetate by Tetramethyl Substituted Cucurbit[6] uril[J].Chinese Journal of Applied Chemistry,2010,27(5):563-566. |
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| Authors: | LI Guo-Ping YU Fang-Qin LIN Jin-He CHEN Yin-Zhi |
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| Institution: | (Department of Chemistry and Environmental Science,Zhangzhou Normal University,Zhangzhou 363000) |
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| Abstract: | The solubility improvement of dexamethasone acetate by tetramethyl substituted cucurbit6]urils(TMeQ6]) was studied with the micro porous filter membrane separation technique,and the solid inclusion complex of TMeQ6] and dexamethasone acetate was analyzed with the method of DTA.The results show that TMeQ6] was able to increase the solubility of dexamethasone acetate,and the solubilization improvement could reach 4~17-fold when the concentration of TMeQ6] increased from 0.04 to 0.28 mmol/L.While the temp... |
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| Keywords: | tetramethyl substituted cucurbit[6]urils dexamethasone acetate solubility improvement inclusion complex |
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