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Equilibrium NH-acidity of 1,4-dihydropyridines and 4,5-dihydroindeno[1,2-b]pyridines
Authors:B A Vigante  M I Terekhova  Ya Ya Ozols  E S Petrov  G Ya Dubur
Institution:(1) Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, 226006 Riga;(2) L. Ya. Karpov Scientific Research Physicochemical Institute, 107120 Moscow
Abstract:The patterns governing the dependence of NH-acidity on the presence of agr-, Bgr- and gamma-substituents in the 1,4-dihydropyridine ring and on their nature have been established by comparison of the pKa values of monocyclic 1,4-dihydropyridines and 4,5-dihydroindenopyridines. Additional data were obtained on the influence of the the electronic effects of sulfur-containing substitutents on the reaction center in the dihydropyridine molecules.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1228–1231, September, 1989.
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