Atmospheric pressure laser desorption/chemical ionization mass spectrometry: a new ionization method based on existing themes |
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Authors: | Coon Joshua J McHale Kevin J Harrison W W |
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Institution: | Department of Chemistry, University of Florida, Gainesville, FL 32611, USA. |
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Abstract: | We have designed and constructed an atmospheric pressure laser desorption/chemical ionization (AP-LD/CI) source that utilizes a laser pulse to desorb intact neutral molecules, followed by chemical ionization via reagent ions produced by a corona discharge. This source employs a heated capillary atmospheric pressure inlet coupled to a quadrupole ion trap mass spectrometer and allows sampling under normal ambient air conditions. Preliminary results demonstrate that this technique provides approximately 150-fold increase in analyte ions compared to the ion population generated by atmospheric pressure infrared matrix-assisted laser desorption/ionization (AP-IR-MALDI). |
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