Preparation of a new FerroPHOS derivative for palladium-catalyzed asymmetric allylic alkylations |
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| Affiliation: | 1. Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA;2. Department of Medicinal Chemistry, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455, USA |
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| Abstract: | 
A new C2-symmetric only cylindrically chiral FerroPHOS derivative possessing (1-methoxy-1-methyl)ethyl substituents was prepared and applied to the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylprop-2-en-1-yl acetate. Both high catalytic activity (up to 500 turnovers) and enantioselectivity (e.e.'s of up to 96.3%) were attained in reactions using the new diphosphine ligand. |
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