| SYNTHETIC STUDIES ON BLOOD COMPATIBLE BIOMATERIALSⅡ. SYNTHESIS OF POLY(ETHYLENEGLYCOL MONOMETHYLLTHER ) METHACRYLATE AND ANTITHROMBOGENICITY OF ITS COPOLYMERS |
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| 引用本文： | 林思聪,王锦,刘晓宁,屠湘同,Charles L. Liotta. SYNTHETIC STUDIES ON BLOOD COMPATIBLE BIOMATERIALSⅡ. SYNTHESIS OF POLY(ETHYLENEGLYCOL MONOMETHYLLTHER ) METHACRYLATE AND ANTITHROMBOGENICITY OF ITS COPOLYMERS[J]. 高分子科学, 1992, 0(2): 119-126 |
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| 作者姓名： | 林思聪 王锦 刘晓宁 屠湘同 Charles L. Liotta |
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| 作者单位： | Department of Chemistry，Nanjing University，Nanjing，Department of Chemistry，Nanjing University，Nanjing，Department of Chemistry，Nanjing University，Nanjing，Department of Chemistry，Nanjing University，Nanjing，School of Chemistry，Georgia Institute of Technology，Atlanta，U. S. A. |
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| 摘 要： | Poly (ethyleneglycol monomethylether) methacrylate (PEGMM)was synthesized by means of the reaction of methacrylyl chloride with sodium monomethylpolyethyleneglycoxide and was characterized by FTIR, ~1H-NMR,and ultraviolet spectrometries. A series of poly (vinyl alcohol)-graft-PEGMM (PVA-g-PEGMM )and methyl methacrylate-PEGMM copolymer (PMMA-PEGMM) were prepared and tested for antithrombogenicity in vitro. The results indicate that the antithrombogenicity of the copolymers basically increases with the increasing of the DP of polyoxyethylene (POE) chain and tends to a plateau after the DP around 114,i.e. the long chain structure of POE is favourable to the antithrombogenicityof its copolymers ;moreover, the extent of the improvement ofantithrombogenicity also relates to the PEGMM content of the copolymers and the kind of the matrix that the POE chains are located on. These results are consistent with the anticipation of the hypothesis of maintaining proteins normal conformations for blood compatible bioraaterials.
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| 收稿时间： | 1991-03-12 |
SYNTHETIC STUDIES ON BLOOD COMPATIBLE BIOMATERIALSⅡ. SYNTHESIS OF POLY(ETHYLENEGLYCOL MONOMETHYLLTHER ) METHACRYLATE AND ANTITHROMBOGENICITY OF ITS COPOLYMERS |
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| LIN Sicong,WANG Jin,LIU Xiaoning,TU Xiangton,Charles L. Liotta. SYNTHETIC STUDIES ON BLOOD COMPATIBLE BIOMATERIALSⅡ. SYNTHESIS OF POLY(ETHYLENEGLYCOL MONOMETHYLLTHER ) METHACRYLATE AND ANTITHROMBOGENICITY OF ITS COPOLYMERS[J]. Chinese Journal of Polymer Science, 1992, 0(2): 119-126 |
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| Authors: | LIN Sicong WANG Jin LIU Xiaoning TU Xiangton Charles L. Liotta |
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| Affiliation: | Department of Chemistry; Nanjing University; Nanjing; School of Chemistry; Georgia Institute of Technology; Atlanta; U. S. A.; |
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| Abstract: | Poly (ethyleneglycol monomethylether) methacrylate (PEGMM)was synthesized by means of the reaction of methacrylyl chloride with sodium monomethylpolyethyleneglycoxide and was characterized by FTIR, ~1H-NMR,and ultraviolet spectrometries. A series of poly (vinyl alcohol)-graft-PEGMM (PVA-g-PEGMM )and methyl methacrylate-PEGMM copolymer (PMMA-PEGMM) were prepared and tested for antithrombogenicity in vitro. The results indicate that the antithrombogenicity of the copolymers basically increases with the increasing of the DP of polyoxyethylene (POE) chain and tends to a plateau after the DP around 114,i.e. the long chain structure of POE is favourable to the antithrombogenicityof its copolymers ;moreover, the extent of the improvement ofantithrombogenicity also relates to the PEGMM content of the copolymers and the kind of the matrix that the POE chains are located on. These results are consistent with the anticipation of the hypothesis of maintaining proteins normal conformations for blood compatible bioraaterials. |
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| Keywords: | Antithrombogenicity Blood compatible biomaterials macromonomer Poly (vinyl alcohol) Copolymer Poly (ethyleneglycol monomethylether) methacrylate |
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