Synthesis of novel 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines as potential protein kinase inhibitors |
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| Authors: | Marko P. Sušnik Michael Schnürch Marko D. Mihovilovic Kurt Mereiter Peter Stanetty |
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| Affiliation: | (1) Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, 1060 Vienna, Austria;(2) Institute for Chemical Technology and Analytics, Vienna University of Technology, Getreidemarkt 9/164, 1060 Vienna, Austria |
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| Abstract: | Abstract A short and efficient sequence for the synthesis of a series of 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines was developed. 1-Phenyl-2-(6-pyrimidinyl)-ethanones, obtained via Weinreb’s methodology, were used in a Hantzsch thiazole cyclization reaction, followed by introduction of the aniline moieties via nucleophilic substitution. Graphical abstract  |
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| Keywords: | Fungicides Heterocycles Nucleophilic aromatic substitutions Cyclizations Weinreb amide |
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