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Effects of gamma irradiation on solid and lyophilised phospholipids |
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| Authors: | G. Stensrud K. Redford G. Smistad J. Karlsen |
| Affiliation: | a School of Pharmacy, Department of Pharmaceutics, University of Oslo, P.O. Box 1068, Blindern, N-0316, Oslo, Norway b Sintef Materials Technology, P.O. Box 124, Blindern, N-0314, Oslo, Norway |
| Abstract: | The effects of gamma irradiation (25 kGy) as a sterilisation method for phospholipids (distearoylphosphatidylcholine and distearoylphosphatidylglycerol) were investigated. 31P-NMR revealed minor chemical degradation of the phospholipids but lower dynamic viscosity and pseudoplasticity, lower turbidity, higher diffusion constant, smaller size, more negative zeta potential and changes in the phase transition behaviour of the subsequently produced liposomes were observed. The observed changes could to some extent be explained by the irradiation-induced degradation products (distearoylphosphatidic acid, fatty acids, lysophospholipids). |
| Keywords: | Phospholipids Liposomes Gamma irradiation Chemical stability Physical stability |
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