| 大黄素/Mg-Al-LDHs纳米杂化物的制备及缓释性能研究 |
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| 引用本文： | 戴肖南,王其鹏.大黄素/Mg-Al-LDHs纳米杂化物的制备及缓释性能研究[J].无机化学学报,2012,28(3):560-564. |
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| 作者姓名： | 戴肖南 王其鹏 |
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| 作者单位： | 山东轻工业学院化学与制药工程学院,济南,250353 |
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| 基金项目： | 山东省中青年科学家科研奖励基金(No.2007BS04026)资助项目 |
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| 摘 要： | 以Mg-Al型层状双金属氢氧化物(Mg-Al-LDHs)为载体,将大黄素分子通过二次组装法成功插入其层间,得到大黄素/Mg-Al-LDHs纳米杂化物。XRD结果显示,Mg-Al-LDHs粒子层间距由0.48 nm增大到3.35 nm。差热曲线(DTA曲线)分析结果表明,该纳米杂化物分子中大黄素的分解温度比纯大黄素的分解温度高50℃。分别在pH 4.8和pH 7.5的缓冲溶液中测定了大黄素/LDHs的缓释性能,结果表明大黄素/LDHs的药品释放速率明显低于二者的物理混合物,并探讨了释放机理。
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| 关 键 词： | 层状双金属氢氧化物(LDHs) 大黄素 插层 缓释 |
Synthesis and Release Behavior of Emodin Intercalated Mg-Al Hydrotalcite-Like Compounds |
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| DAI Xiao-Nan and WANG Qi-Peng.Synthesis and Release Behavior of Emodin Intercalated Mg-Al Hydrotalcite-Like Compounds[J].Chinese Journal of Inorganic Chemistry,2012,28(3):560-564. |
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| Authors: | DAI Xiao-Nan and WANG Qi-Peng |
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| Institution: | Department of Chemical Engineering, Shandong Polytechnic University, Jinan 250353, China and Department of Chemical Engineering, Shandong Polytechnic University, Jinan 250353, China |
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| Abstract: | In this paper,emodins were successfully intercalated into the gallery of Mg-Al hydrotalcite-like compounds(LDHs),to obtain nanohybrids.The results of X-ray powder diffraction(XRD) showed that the interlayer distance of Mg-Al-LDHs was increased from 0.48 nm to 3.35 nm.The DTA results suggested that the discomposition temperature of the nanohybrids increased by 50 ℃ in comparison with that of emodin.The determination results of the drug release indicated that the drug release rate from the emodin/LDHs nanohybrids was much slower than that from the corresponding physical mixture at either pH 4.8 or pH 7.5.The release mechanism was discussed. |
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| Keywords: | layered double hydroxides(LDHs) emodin intercalation controlled release |
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