Robust antimicrobial compounds and polymers derived from natural resin acids |
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| Authors: | Wang Jifu Chen Yung Pin Yao Kejian Wilbon Perry A Zhang Wujie Ren Lixia Zhou Juhua Nagarkatti Mitzi Wang Chunpeng Chu Fuxiang He Xiaoming Decho Alan W Tang Chuanbing |
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| Affiliation: | Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, Nanjing 210042, China. |
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| Abstract: | We report novel robust resin acid-derived antimicrobial agents that exhibit excellent antimicrobial activities against a broad spectrum of bacteria (6 Gram-positive and 7 Gram-negative) with selective lysis of microbial membranes over mammalian membranes. Our results indicate that hydrophobicity and unique structures of resin acids can be determining factors in dictating the antimicrobial activity. |
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