Total syntheses of arenamides A,B and C |
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Affiliation: | 1. Department of Chemistry, 930 N University, Ann Arbor, MI 48109-1055, United States;2. Program in Applied Physics, 930 N University, Ann Arbor, MI 48109-1055, United States |
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Abstract: | Total syntheses of the three arenamides A–C, NFκB inhibitors, are described for the first time. The key steps involved in the synthesis are a Crimmin’s aldol, Wittig olefination and a macrolactamization reaction. |
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