Synthesis, Crystal Structure and Antibacterial Activity of Two Hydrazones Derived from 2-Fluorobenzhydrazide |
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| Authors: | PAN Xiao-Qiua HUANG Shan-Shana WANG Feib FAN Huib LENG Huia ZHANG Hou-Lia DIAO Yun-Peng |
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| Institution: | PAN Xiao-Qiua HUANG Shan-Shana WANG Feib FAN Huib LENG Huia ZHANG Hou-Lia② DIAO Yun-Penga② a (College of Pharmacy, Dalian Medical University, Dalian 116044, China) b (Liaoning University of Traditional Chinese Medicine, Dalian 116044, China) |
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| Abstract: | Two new Schiff base benzoyl hydrazone compounds, C14H10FN3O3 (Ⅰ) and C14H10F2N2O (Ⅱ), have been synthesized and characterized by elemental analysis, IR, UV and X-ray single-crystal diffraction. Both compounds crystallize in monoclinic, space group P21/c with a = 7.0514(14), b = 25.928(5), c = 7.7099(15), β = 111.823(2)°, V = 1308.6(4)3, Z = 4, C14H10FN3O3, Mr = 287.25, Dc = 1.458 g/cm3, μ(MoKα) = 0.115 mm-1, F(000) = 592, the final R = 0.0841 and wR = 0.2489 for 1901 observed reflections (I > 2σ(I)) for I; a = 11.232(3), b =12.735(4), c = 8.612(2) , β = 90.869(3)°, V = 1231.7(6)3, Z = 4, C14H10F2N2O, Mr = 260.24, Dc = 1.403 g/cm3, μ(MoKα) = 0.111 mm-1, F(000) = 536, the final R = 0.0453 and wR = 0.1085 for 1317 observed reflections (I > 2σ(I)) for Ⅱ. The antibacterial activities of both compounds against two bacteria were first studied and one compound showed considerable antibacterial activity against K. Pneumonia and S. aureus. |
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| Keywords: | Schiff base hydrazone crystal structure antibacterial activity |
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