Development of Phosphatidylethanolamine Liposomes That Efficiently Retain Encapsulated Vinorelbine Bitartrate

A hydrophilic and temperature-induced degradation drug, vinorelbine bitartrate (VB)-loaded phosphatidylethanolamin sterically stabilized liposomes (PSLs) were prepared by the thin film hydration method. Liposomes were made of phosphatidylethanolamine: cholesteryl: oleic acid (PE: CHOL: OA, 6:4:3 mass/mass). The mean particle size of the PSLs ranged from 600 to 650 nm. The transmission electron microscope (TEM) images displayed that the shape of the PSLs was multilamellar vesicles with smooth surface. The highest entrapment efficiency (EE) and drug loading capacity (DL) could reach up to 81.2 and 16.6%, respectively. The studies of drug release showed that the drug release could last for much more than 48 hours. The PSLs was evaluated by comparing the rate of release of encapsulated VB in different phosphate buffer solution (PBS).