Study of Partitioning and Solubilization of Some New Chalcones Between Aqueous and Micellar Phases

The partitioning behavior of four newly synthesized chalcones between aqueous and micellar phases of ionic surfactants (SDS and CTAB) was investigated using ultraviolet-visible spectroscopy. The simple absorption spectra were recorded to study the interaction between these drugs and surfactants (in the concentration range below critical micelle concentration to above critical micelle concentration). The absorption data is also used to determine the number of additive molecules incorporated per micelle of the surfactant. The partition coefficient (K_x) of additives between bulk water phase and the micellar phase was determined in the range of 5.52 × 10⁺⁴ to 5.06 × 10⁺⁵ at 298 K by differential spectroscopic method. The corresponding standard free energy of partition ΔG°_p obtained was in the range of ?27.05 kJmol^?1 to ?32.54 kJmol^?1. The relative solubility of additives between aqueous and micellar phases in different micellar concentrations was also estimated. The results showed that the chalcones are preferably soluble in cationic surfactant micelles.