Analysis of the Phase Changes During Evaporation of Emulsions with Different Oil Phases |
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Authors: | Orlando D H Santos Maria Fernanda P Camargo Kauê P Boock Mateus M Bergamaschi Pedro A Rocha Filho |
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Institution: | 1. Department of Pharmacy , School of Pharmacy, Federal University of Ouro Preto , Ouro Preto, Brazil orlando@ef.ufop.br;3. Department of Pharmaceutical Science , Faculty Pharmaceutical Science of Ribeir?o Preto, University of Sao Paulo , Sao Paulo, Brazil |
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Abstract: | Emulsions surfer alterations in their microstructure after applied on the skin, because of the interaction with skin constituents and mainly by the evaporation of volatile components. These alterations are not even considered by cosmetic formulators, but they are extremely important because they can act on formulation stability, on delivery and on permeation of actives and also on the ability to build the occlusive film, responsible for skin's moisturization. This research studied the phase changing during evaporation of emulsions made with three different oil phase: mineral oil, avocado oil, and isocethyl/stearoil stearate, as a function of the decrease on water ratio, using phase diagrams and evaporation test. It was observed the formation of liquid crystalline phases and their transition along the evaporation path for emulsions with the three different oil phases. It was also observed that these transitions occurred in different water ratios. |
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Keywords: | Avocado oil evaporation isocethyl/stearoil stearate lamellar liquid crystal mineral oil phase diagram structural changes |
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