| 间二氟苯溴化反应产物的气相色谱-质谱分析 |
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| 引用本文： | 叶发青,李艳霞,郭平,刘剑敏.间二氟苯溴化反应产物的气相色谱-质谱分析[J].分析科学学报,2007,23(4):445-448. |
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| 作者姓名： | 叶发青 李艳霞 郭平 刘剑敏 |
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| 作者单位： | 1. 温州医学院药学院,浙江温州,325035
2. 温州医学院分析测试中心,浙江温州,325035 |
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| 摘 要： | 采用气相色谱-质谱(GC/MS)法对间二氟苯溴化反应产物的组成与结构进行了分析,并对间二氟苯溴化反应的选择性及反应条件进行了初步探讨。结果表明:间二氟苯的溴化反应具有较强的选择性,其主要反应产物为1-溴-2,4-二氟苯,副产物为1-溴-2,6-二氟苯、1-溴-3,5二氟苯及二溴代间二氟苯等溴化物。该反应的反应条件对产物组成有较大影响。
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| 关 键 词： | 间二氟苯 溴化反应 气相色谱-质谱 |
| 文章编号： | 1006-6144（2007）04-0445-04 |
| 修稿时间： | 2007-02-06 |
Gas Chromatography-Mass Spectrometric Analysis of the Products of m-difluorobenzene by Bromination Reaction |
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| YE Fa-qing,LI Yan-xia,GUO Ping,LIU Jian-min.Gas Chromatography-Mass Spectrometric Analysis of the Products of m-difluorobenzene by Bromination Reaction[J].Journal of Analytical Science,2007,23(4):445-448. |
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| Authors: | YE Fa-qing LI Yan-xia GUO Ping LIU Jian-min |
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| Institution: | 1. Department of Pharmaceutical Chemistry, Wenzhou Medical College, Wenzhou , Zhejiang 325035 ; 2. Analytical and Testing Center, Wenzhou Medical College, Wenzhou , Zhejiang 325035 |
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| Abstract: | The m-difluorobenzene was brominated.The composition and structure of products were analyzed by gas chromatography/mass spectrometry.The selectivity and conditions of bromination was also discussed preliminarily.The results show that this bromination reaction has better selectivity.The mainly product is 1-bromo-2,4-difluorobenzene in this reaction.There is mainly three bromination by-products in reaction,such as 1-bromo-2,6-difluorobenzene,1-bromo-3,5-difluorobenzene and dibromide.The results of GC/MS determination show that there are relatively large effects of the reaction condition on products. |
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| Keywords: | m-Difluorobenzene Bromination Gas chromatography/mass spectrometry |
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