One-pot syntheses of novel pyrazole-containing bisphosphonate esters at room temperature |
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| Authors: | Haoyue Xiang Xueyu Qi Yuyuan Xie Guangyu Xu Chunhao Yang |
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| Institution: | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, P. R. China. chyang@mail.shcnc.ac.cn. |
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| Abstract: | An efficient general synthetic approach has been developed to synthesize pyrazole-containing bisphosphonate (N-BPs) esters from chromenone derivatives via a sequential two-step reaction in one pot at ambient temperature in good to excellent yields. This protocol provides a new convenient method to prepare lipophilic bisphosphonate precursors with potential activities. |
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