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Synthesis of piperidinones incorporating an amino acid moiety as potential SP antagonists
Authors:Nikola Burdzhiev  Elena Stanoeva  
Affiliation:a Department of Organic Chemistry, Faculty of Chemistry, St. Kliment Ohridski University of Sofia, 1, J. Bourchier Avenue, 1164 Sofia, Bulgaria
Abstract:Substituted (±)-trans-1-benzyl-6-oxo-2-phenylpiperidine-3-carboxamides (type I) and the acylated derivatives of (±)-trans-5-amino-1-benzyl-6-phenylpiperidin-2-one (type II) were prepared by the reaction of (±)-trans-1-benzyl-6-oxo-2-phenylpiperidine-3-carboxylic acid and some common reagents to provide the products in satisfactory yields. Newly synthesized compounds share the same moiety with common SP antagonists and thus similar activities might be expected.
Keywords:Piperidinones   Peptide bond   Hofmann Rearrangement   Configuration determination   SP antagonists
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