Synthesis of piperidinones incorporating an amino acid moiety as potential SP antagonists |
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Authors: | Nikola Burdzhiev Elena Stanoeva |
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Affiliation: | a Department of Organic Chemistry, Faculty of Chemistry, St. Kliment Ohridski University of Sofia, 1, J. Bourchier Avenue, 1164 Sofia, Bulgaria |
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Abstract: | Substituted (±)-trans-1-benzyl-6-oxo-2-phenylpiperidine-3-carboxamides (type I) and the acylated derivatives of (±)-trans-5-amino-1-benzyl-6-phenylpiperidin-2-one (type II) were prepared by the reaction of (±)-trans-1-benzyl-6-oxo-2-phenylpiperidine-3-carboxylic acid and some common reagents to provide the products in satisfactory yields. Newly synthesized compounds share the same moiety with common SP antagonists and thus similar activities might be expected. |
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Keywords: | Piperidinones Peptide bond Hofmann Rearrangement Configuration determination SP antagonists |
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