Interactions of oxidative radicals with N-phosphoryl dipeptide derivatives |
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| Authors: | CHU Gao-Sheng CHEN Jia-Fu ZHANG Zhi-Cheng |
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| Institution: | CHU,Gao-Sheng CHEN,Jia-Fu ZHANG,Zhi-Cheng
Department of Applied Chemistry,University of Science and Technology of China,Hefei,Anhui 230026,China
YAO,Si-De
Laboratory of Radiation Chemistry,Chinese Academy of Sciences,Shanghai Institute of Nuclear Research,Shanghai 201800,China |
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| Abstract: | The interactions of oxidative radicals (Br2 , HO etc.) with N-phosphoryl dipeptide derivatives (NDM-TrpOMe and NDT-MetOMe) have been investigated by using pulse radiolysis at different pH values. It
has been found that Br2 and HO radicals oxidize the Met-site and Trp-site in the dipeptide derivatives via formation of the three-electron-bonded intermediate and indolyl radical simultaneously. Then the intramolecular electron transfer along the peptide backbone occurs. The rate constants of electron transfer, k, have been determined and the reaction mechanism has been deduced. |
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| Keywords: | N-Phosphoryl dipeptide oxidation electron transfer pulse radiolysis |
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