| 高效液相色谱法直接拆分泮托拉唑钠对映体 |
| |
| 引用本文： | 丁国生,丛润滋,王俊德. 高效液相色谱法直接拆分泮托拉唑钠对映体[J]. 色谱, 2004, 22(3): 241-243 |
| |
| 作者姓名： | 丁国生 丛润滋 王俊德 |
| |
| 作者单位： | 中国科学院大连化学物理研究所,辽宁,大连,116012 |
| |
| 摘 要： | 首次使用Kromasil CHI-TBB手性柱在正相条件下直接拆分了泮托拉唑钠对映异构体,考察了流动相组成、酸碱调节剂用量以及流速对对映体分离的影响。优化后的分析条件为:流动相组成为正己烷-异丙醇-乙酸(体积比为95∶5∶0.1)混合溶液，流速2.0 mL/min，柱温25 ℃。所建立的方法具有柱效高、简便快捷及重复性好等优点。
|
| 关 键 词： | 高效液相色谱法 泮托拉唑钠对映体 手性分离 手性固定相 |
| 文章编号： | 1000-8713(2004)03-0241-03 |
| 修稿时间： | 2003-07-25 |
Direct Enantiomeric Separation of Pantoprazole Sodium by High Performance Liquid Chromatography |
| |
| DING Guosheng,CONG Runzi,WANG Junde. Direct Enantiomeric Separation of Pantoprazole Sodium by High Performance Liquid Chromatography[J]. Chinese journal of chromatography, 2004, 22(3): 241-243 |
| |
| Authors: | DING Guosheng CONG Runzi WANG Junde |
| |
| Affiliation: | Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116012, China. |
| |
| Abstract: | By using the Kromasil CHI-TBB chiral stationary phase, the racemic mixture of pantoprazole sodium was resolved in the normal phase mode. The influences of the composition of the mobile phase, the content of acidic and basic additives and the flow rate on this enantiomer separation were studied. The chiral high performance liquid chromatographic method for the analysis of pantoprazole sodium was established with high efficiency and good repeatability, by using hexane-isopropanol-acetic acid mixture (95:5:0.1, v/v) as the mobile phase at a flow rate of 2.0 mL/min at 25 degrees C. |
| |
| Keywords: | high performance liquid chromatography chiral stationary phase pantoprazole sodium enantiomers chiral separation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《色谱》浏览原始摘要信息 |
|
点击此处可从《色谱》下载全文 |
