Combinatorial Screening of Water/Proton Permeation of Self-Assembled Pillar[5]arene Artificial Water Channel Libraries |
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| Authors: | Iuliana-Marilena Andrei Dmytro Strilets Dr. Shixin Fa Marc Baaden Prof. Tomoki Ogoshi Dr. Mihail Barboiu |
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| Affiliation: | 1. Institut Europeen des Membranes, Adaptative Supramolecular Nanosystems Group, University of Montpellier, ENSCM-CNRS, Place E. Bataillon CC047, 34095 Montpellier, France;2. Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University Katsura, Nishikyo-ku, Kyoto, 615-8510 Japan;3. Université Paris Cité, CNRS, Laboratoire de Biochimie Théorique, 13 rue Pierre et Marie Curie, 75005 Paris, France |
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| Abstract: | Artificial water channels (AWCs) that selectively transport water and reject ions through bilayer membranes have potential to act as synthetic Aquaporins (AQPs). AWCs can have a similar osmotic permeability, better stability, with simpler manufacture on a larger-scale and have higher functional density and surface permeability when inserted into the membrane. Here, we report the screening of combinatorial libraries of symmetrical and unsymmetrical rim-functionalized PAs A – D that are able to transport ca. 107–108 water molecules/s/channel, which is within 1 order of magnitude of AQPs’ and show total ion and proton rejection. Among the four channels, C and D are 3–4 times more water permeable than A and B when inserted in bilayer membranes. The binary combinations of A – D with different molar ratios could be expressed as an independent (linear ABA ), a recessive (inhibition AB , AC , DB , ACA ), or a dominant (amplification, DBD ) behavior of the water net permeation events. |
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| Keywords: | artificial water channels pillar[5]arene self-assembly dynamic combinatorial libraries bilayer membranes |
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