Total syntheses of variolin B and deoxyvariolin B |
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| Authors: | Ahaidar Abderaouf Fernández David Danelón Gerardo Cuevas Carmen Manzanares Ignacio Albericio Fernando Joule John A Alvarez Mercedes |
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| Affiliation: | Barcelona Biomedical Research Institute, Barcelona Scientific Park, University of Barcelona, Josep Samitier 1-5, E 08028 Barcelona, Spain. |
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| Abstract: | ![]()
Two alternative synthetic routes have been developed for the preparation of variolin B and deoxyvariolin B. The strategy is based on the preparation of the core tricyclic ring common to all variolins, pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine, followed by a palladium-catalyzed cross-coupling reaction to give the tetracyclic system. |
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