Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones |
| |
| Authors: | Alicia Monleó n,Gonzalo Blay,José R. Pedro |
| |
| Affiliation: | Departament de Química Orgànica, Facultad de Química, Universitat de València, C/Dr. Moliner 50, 46100 Burjassot, Spain; |
| |
| Abstract: | ![]()
A convenient procedure of synthesis of N-carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding products in good yields and enantioselectivities. |
| |
| Keywords: | N-carbamoyl-protected propargylic amines, α -amido sulfones, cyclopropylacetylene, BINOL, zinc complex |
|
|
