A Novel Method for the Synthesis of Spiro[indoline‐Pyrazolo[4′,3′:5,6]pyrido[2,3‐d]pyrimidine]triones by Alum as a Reusable Catalyst |
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| Authors: | Sadif A. Shirvan Ramin Ghahremanzadeh Mojtaba Mirhosseini Moghaddam Ayoob Bazgir Amir Hassan Zarnani Mohammad Mehdi Akhondi |
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| Affiliation: | 1. Department of Chemistry, Islamic Azad University, Omidieh Branch, , Omidieh, Iran;2. Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, , Tehran, Iran;3. Department of Chemistry, Shahid Beheshti University, G.C., , Tehran, Iran;4. Immunology Research Center, Iran University of Medical Sciences, , Tehran, Iran;5. Reproductive Research Center, Avicenna Research Institute, ACECR, , Tehran, Iran |
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| Abstract: | Synthesis of spiro[indoline‐pyrazolo[4′,3′:5,6]pyrido[2,3‐d]pyrimidine]trione derivatives by a cyclo‐condensation reaction of indolin‐2‐ones, barbituric acids, and 1,3‐diphenyl‐1H‐pyrazol‐5‐amines with the ionic liquid as an effective green reaction media and in the presence of Alum as a reusable catalyst was reported. Excellent yields of products, green media, use of a reusable catalyst, and short reaction time are the main advantages of this new method. |
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