Synthesis and Antimicrobial Activity of 4‐(10H‐Phenothiazin‐2‐yl)‐pyrimidin‐2(1H)‐one/thione Derivatives

A series of chalcones 3a , 3b , 3c , 3d containing phenothiazine nucleus were prepared by Claisen–Schmidt condensation. The chalcones on treatment with urea, thiourea, phenyl urea, and phenyl thiourea in alcoholic KOH yielded compounds 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j , 4k , 4l , 4m , 4n , 4o , 4p , and the structures of these compounds were confirmed by spectral and elemental analyses. The newly synthesized compounds were evaluated for antimicrobial activity.