Synthesis of 6‐Aminopropyl‐6H‐indolo[2,3‐b]quinoxaline Derivatives |
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| Authors: | Marina O. Shibinskaya Nina A. Kutuzova Alexandr V. Mazepa Sergey A. Lyakhov Sergey A. Andronati Mykhayl Ju. Zubritsky Valerij F. Galat Janusz Lipkowski Victor Ch. Kravtsov |
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| Affiliation: | 1. A.V. Bogatsky Physico‐Chemical Institute of NAS of Ukraine, , Odessa, 65080 Ukraine;2. Odessa National I.I. Mechnikov University, , Odessa, 65026 Ukraine;3. L. M. Litvinenko Institute of Physical‐Organic Chemistry and Coal Chemistry of the NAS of Ukraine, , Donetsk, 83114 Ukraine;4. Institute of Physical Chemistry, Polish Academy of Sciences, , Warsaw, 01‐224 Poland;5. Institute of Applied Physics, Academy of Sciences of Moldova, , Chi?in?u, R. Moldova |
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| Abstract: | A series of 6‐(3‐aminopropyl)‐6H‐indolo[2,3‐b]quinoxalines were synthesized with high yields by the reaction of 6‐(3‐chloropropyl)‐6H‐indolo[2,3‐b]quinoxaline and corresponding amines in presence of tetrabutylammonium iodide in boiling toluene or dimethylformamide at room temperature. It was found that boiling of 6‐(3‐chloropropyl)‐6H‐indolo[2,3‐b]quinoxaline in acetone with sodium iodide or in acetic acid lead to intramolecular cyclization product. |
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