Spectrophotometric determination of clozapine in pharmaceuticals |
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| Authors: | Chilukuri S. P. Sastry Thuta Vijaya Rekha Atreyapurapu Satyanarayana |
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| Affiliation: | (1) Department of Organic Chemistry, Foods, Drags and Water, Andhra University, 530003 Visakhapatnam, India;(2) Department of Physical Chemistry, Andhra University, 530003 Visakhapatnam, India |
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| Abstract: | New Spectrophotometric methods for the assay of clozapine (CZP) in pure and dosage forms are described. Method A is based on the oxidative coupling reaction of CZP with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in the presence of ceric ammonium sulphate to form a coloured species ( max 570 nm). Method B is also based on the oxidative coupling reaction of CZP withP-,N,N-dimethylpheny-lenediamine dihydrochloride (DMPD) in the presence of sodium hypochlorite to form a coloured species (max 690 nm). Method C is based on the formation of coloured charge-transfer complex between CZP and chloranilic acid (max 540 nm). Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges 2–25, 10–120 and 15–300  g/ml for methods A, B and C, respectively. The validity of the proposed methods was tested by analysing pharmaceutical dosage forms containing CZP and the relative standard deviation values were within 1.0%. |
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| Keywords: | clozapine 3-methyl-2-benzothiazolinone hydrazone hydrochloride p-N,N-dimethylphenylenediamine dihydrochloride chloranilic acid pharmaceuticals visible spectrophotometry |
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