青霉素G钾盐对SDS水溶液物理化学性质的影响及其在SDS/n-C5H11OH/H2O体系中的释放

The effects of penicillin potassium salt （PenK） on the solubility, Krafft temperature TK, critical micelle concentration CMC of SDS micelle and the phase behavior of SDS/n-C5H11OH/H2O system were studied. The partial phase diagrams of SDS/PenK/H2O system at different temperatures were determined. The release amounts of PenK in SDS/n-C5H11OH/H2O system and the distribution coefficient of PenK between micelle and water were measured by UV-Vis spectroscopy. The results show that in the presence of PenK, the CMC of SDS was decreased while the TK of SDS was increased and the solubility of SDS in both water and SDS/n-C5H11OH/H2O oil in water （O/W） microemulsion was decreased, but increased in water in oil （W/O） microemulsion. SDS micelles and SDS/n- C5H11OH/H20 O/W microemulsion could accelerate the release rate of PenK. The addition of SDS and water could both increase the release rate of PenK, whereas the presence of n-C5H11OH reduced the release rate of PenK. The above results were related to the electrostatic repulsion between PenK and SDS.

Effect of Penicillin G Potassium Salt on the Physicochemical Properties of SDS Aqueous Solution and the Release of the Salt in SDS/n-CsH11OH/H2O System

The effects of penicillin potassium salt (PenK) on the solubility, Krafft temperature T_K, critical micelle concentration CMC of SDS micelle and the phase behavior of SDS/n‐C₅H₁₁OH/H₂O system were studied. The partial phase diagrams of SDS/PenK/H₂O system at different temperatures were determined. The release amounts of PenK in SDS/n‐C₅H₁₁OH/H₂O system and the distribution coefficient of PenK between micelle and water were measured by UV‐Vis spectroscopy. The results show that in the presence of PenK, the CMC of SDS was decreased while the T_K of SDS was increased and the solubility of SDS in both water and SDS/n‐C₅H₁₁OH/H₂O oil in water (O/W) microemulsion was decreased, but increased in water in oil (W/O) microemulsion. SDS micelles and SDS/n‐C₅H₁₁OH/H₂O O/W microemulsion could accelerate the release rate of PenK. The addition of SDS and water could both increase the release rate of PenK, whereas the presence of n‐C₅H₁₁OH reduced the release rate of PenK. The above results were related to the electrostatic repulsion between PenK and SDS.