The effect of pH on solubilization of weak acids and bases |
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| Affiliation: | 1. Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin St., PL- 87-100 Toruń, Poland;2. Department of Toxicology and Bromatology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, dr. A. Jurasza 2, 85-089 Bydgoszcz, Poland;1. Department of Pharmaceutics and Pharmaceutical Technology, The British University in Egypt (BUE), Cairo, Egypt;2. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt;3. Department of Pharmacology and Toxicology, The British University in Egypt (BUE), Cairo, Egypt;1. Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA;2. International Consultancy in Blood Components Quality/Safety Improvement & DDR Strategies, London, UK;3. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA;1. School of Civil Engineering, Harbin Institute of Technology, Harbin 150090, China;2. Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education, Harbin Institute of Technology, Harbin 150090, China;3. Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information Technology, Harbin Institute of Technology, Harbin 150090, China;4. FAW GROUP, Changchun 130011, China |
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| Abstract: | Recent studies of the nature of surface-active agents in solution indicate that micelles formed in such solutions behave somewhat as a separate phase. Solubility measurements were made on o-phenylphenol, pentachlorophenol, and p-dimethylaminoazobenzene in solutions with and without surfactant over a wide pH range. The ratio of solubility in a surfactant solution to solubility in a similar solution without surfactant is defined as relative solubilization. This varies with solution pH and solute pK, being at a maximum for nonionized solute and at half-maximum when pH is equal to pK. The variation of relative solubilization with pH is that which is predicted from treatment of micelles as a separate phase. |
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