Electrocatalytic oxidation of aspirin and acetaminophen on a cobalt hydroxide nanoparticles modified glassy carbon electrode |
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Authors: | M Houshmand A Jabbari H Heli M Hajjizadeh A A Moosavi-Movahedi |
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Institution: | (1) Department of Chemistry, Faculty of Science, K. N. Toosi University of Technology, P.O. Box: 16315-1618, Tehran, Iran;(2) Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran |
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Abstract: | The electrocatalytic oxidation of aspirin and acetaminophen on nanoparticles of cobalt hydroxide electrodeposited on the surface
of a glassy carbon electrode in alkaline solution was investigated. The process of oxidation and the kinetics have been investigated
using cyclic voltammetry, chronoamperometry, and steady-state polarization measurements. Voltammetric studies have indicated
that in the presence of drugs, the anodic peak current of low valence cobalt species increases, followed by a decrease in
the corresponding cathodic current. This indicates that drugs are oxidized on the redox mediator which is immobilized on the
electrode surface via an electrocatalytic mechanism. With the use of Laviron’s equation, the values of anodic and cathodic
electron-transfer coefficients and charge-transfer rate constant for the immobilized redox species were determined as α
s,a = 0.72, α
s,c = 0.30, and k
s = 0.22 s−1. The rate constant, the electron transfer coefficient, and the diffusion coefficient involved in the electrocatalytic oxidation
of drugs were reported. It was shown that by using the modified electrode, aspirin and acetaminophen can be determined by
amperometric technique with detection limits of 1.88 × 10−6 and 1.83 × 10−6 M, respectively. By analyzing the content of acetaminophen and aspirin in bulk forms using chronoamperometric and amperometric
techniques, the analytical utility of the modified electrode was achieved. The method was also proven to be valid for analyzing
these drugs in urine samples. |
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Keywords: | Aspirin Acetaminophen Electrocatalysis Nanoparticles Cobalt oxide |
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