A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation |
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| Authors: | Steven M. Gaulier Reuben McKayNigel A. Swain |
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| Affiliation: | World Wide Medicinal Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK |
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| Abstract: | A novel three linear step synthesis of Celecoxib was achieved in 33% overall yield via a key regioselective direct C-H arylation reaction between a 1,3-disubstituted pyrazole and an aryl bromide. |
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| Keywords: | Direct arylation Celecoxib Pd catalysis |
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