Studies on the Synthesis of Reidispongiolide A: Stereoselective Synthesis of the C(22)-C(36) Fragment |
| |
| Authors: | Ying Maben Roush William R |
| |
| Institution: | Department of Chemistry, The Scripps Research Institute, Florida, 130 Scripps Way, Jupiter, FL 33458, USA |
| |
| Abstract: | A highly stereoselective synthesis of the C(22)-C(36) fragment 2 of reidispongiolide A is described. This synthesis features the highly stereoselective mismatched double asymmetric crotylboration reaction of the aldehyde derived from 5 and the new chiral reagent (S)-(E)-7 that provides 12 with >15:1 dr. Subsequent coupling of the derived vinyl iodide 3 with aldehyde 16 provided allylic alcohol 17, that was elaborated by three steps into the targeted reidispongiolide fragment 2. |
| |
| Keywords: | Studies on the synthesis of reidispongiolide A Mismatched double asymmetric crotylboration Stereoselective synthesis of the anti anti stereotriad |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
