3－烷基-4-羟基-2-噻唑烷硫酮-4-羧酸乙酯的一锅煮合成

Ethyl 3-alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates were prepared in excellent yields from the reaction of corresponding primary amines with carbon disulfide and ethyl 3-bromo-2-oxopropanoate in the presence of anhydrous potassium phosphate in DMF at room temperature within 1 h. The structures of the highly functionalized products were corroborated spectroscopically （IR, ^1H NMR, ^13C NMR, EI-MS） and by elemental analyses. A plausible mechanism for such type of cyclization was proposed.

Facile One-pot Synthesis of Ethyl 3-Alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates

Ethyl 3‐alkyl‐4‐hydroxy‐2‐thioxothiazolidine‐4‐carboxylates were prepared in excellent yields from the reaction of corresponding primary amines with carbon disulfide and ethyl 3‐bromo‐2‐oxopropanoate in the presence of anhydrous potassium phosphate in DMF at room temperature within 1 h. The structures of the highly functionalized products were corroborated spectroscopically (IR, ¹H NMR, ¹³C NMR, EI‐MS) and by elemental analyses. A plausible mechanism for such type of cyclization was proposed.