Rapid Eco-Friendly Synthesis and Structure of 3-Hydroxy-3-nitromethyl-1,3-dihydro-indol-2-one |
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| Authors: | Gang Chen Ying Tang Qun-Zheng Zhang Ya Wu Shun-Zhen Mu |
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| Institution: | (1) College of Chemistry & Chemical Engineering, Xi’an Shiyou University, Xi’an, Shaanxi, 710065, People’s Republic of China;(2) Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guizhou, Guiyang, 550002, People’s Republic of China |
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| Abstract: | Abstract 3-Hydroxy-3-nitromethyl-1,3-dihydro-indol-2-one was synthesized from isatin by Henry reaction using an eco-friendly method
and characterized by NMR and MS. The crystal structure was determined from single-crystal X-ray diffraction data. It crystallizes
in the orthorhombic space group, Pbca, with unit cell dimensions a = 10.515 (2) Å, b = 7.3736 (14) Å, and c = 23.261 (4) Å. The two rings are coplanar and the angle between hydroxyl group and nitromethyl group is 109.07(9)°. In the
crystal structure, intermolecular N–H···O and O–H···O hydrogen bonds are responsible for the formation of a 3-dimensional
network. No intramolecular hydrogen bond exists. |
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