Highly enantioselective Mukaiyama aldol reaction in aqueous conditions using a chiral iron(II) bipyridine catalyst |
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| Authors: | Ollevier Thierry Plancq Baptiste |
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| Affiliation: | Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec (Québec), G1V 0A6, Canada. thierry.ollevier@chm.ulaval.ca |
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| Abstract: | A highly enantioselective method for the catalytic Mukaiyama aldol reaction of silyl enol ethers with aldehydes in aqueous conditions was developed. The desired aldol products were obtained in excellent yields, diastereo- and enantioselectivities. Structural evidence of the pre-catalyst revealed an unprecedented heptadentate Fe(II) complex with the chiral bipyridine ligand. |
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