三(邻甲基苄基)锡和二(间氟苄基)锡硫代水杨酸酯配合物的合成、结构及性质

合成了三(邻甲基苄基)锡硫代水杨酸酯配合物(1)和一维链状二(间氟苄基)锡硫代水杨酸酯配合物(2),经元素分析、IR、NMR、X射线衍射等技术手段表征了其结构。配合物1属三斜晶系,空间群Pī,晶体学参数a=1.00221(5)nm,b=1.48934(8)nm,c=1.71789(9)nm,α=78.3120(10)°,β=85.6560(10)°,γ=80.2580(10)°,V=2.4725(2)nm~3,Z=2,Dc=1.371 g/cm~3,μ(Mo Kα)=10.91 cm~(-1),F(000)=1040,R_1=0.0439,wR_2=0.1119。配合物2属单斜晶系,空间群为P21/n,晶体学参数:a=1.17827(5)nm,b=2.11945(9)nm,c=1.55970(7)nm,β=93.4510(10)°,V=3.8880(3)nm~3,Z=4,Dc=1.671 g/cm~3,μ(Mo Kα)=14.53 cm~(-1),F(000)=1936,R1=0.0323,wR2=0.0927。配合物1中锡原子呈四配位畸变四面体构型,配合物2中锡原子呈五配位畸变三角双锥构型。配合物1和2分别在152和195℃下稳定,电化学性质不可逆,对人体癌细胞Colo205、Hep G2、MCF-7、Hela和NCI-H460具有体外抗癌活性,配合物2的抗癌活性远大于配合物1。

Synthesis,Structures and Properties of Tris(o-methylbenzyl)tin Thiosalicylate and Di(m-fluorobenzyl)tin Thiosalicylate

Tris(o-methylbenzyl)tin thiosalicylate(1) and di(m-fluorobenzyl)tin thiosalicylate(2) have been synthesized. Crystal structures of the complexes were determined by X-ray diffraction. Crystal 1 belongs to the triclinic space group Pī with a=1.00221(5) nm, b=1.48934(8) nm, c=1.71789(9) nm, α=78.3120(10)°, β=85.6560(10)°, γ=80.2580(10)°, V=2.4725(2) nm³, Z=2, D_c=1.371 g/cm³, μ(MoKα)=10.91 cm^-1, F(000)=1040, R₁=0.0439, wR₂=0.1119. Crystal 2 belongs to the monoclinic space group P2₁/n with a=1.17827(5) nm,b=2.11945(9) nm,c=1.55970(7) nm,β=93.4510(10)°,V=3.8880(3) nm³,Z=4,D_c=1.671 g/cm³,μ(MoKα)=14.53 cm^-1,F(000)=1936,R₁=0.0323,wR₂= 0.0927. The tin atoms in complexes 1 and 2 have four coordinates in a distorted tetrahedral configuration and five coordinates in a distorted trigonal bipyramidal configuration, respectively. Further more, the thermal stability and electrochemical and anticancer activity of the complexes were tested. The results show that complexes 1 and 2 are stable below 152 ℃ and below 195 ℃, respectively, and show irreversible redox process. Complexes 1 and 2 display in vitro anti-tumor activity against five human tumor cell lines Colo205, Hep G2, MCF-7, Hela and NCI-H460, and the anti-tumor activity of complex 2 is higher than that of complex 1.