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| 溴酸钠和氯化铁为助催化剂2,2,6,6-四甲基-N-氧化哌啶催化醇的氧化 | |
| 引用本文： | 褚朝森,王晓丽,胡玉涛,闫秀美,王政. 溴酸钠和氯化铁为助催化剂2,2,6,6-四甲基-N-氧化哌啶催化醇的氧化[J]. 应用化学, 2015, 32(6): 666-670. DOI: 10.11944/j.issn.1000-0518.2015.06.140331 |
| 作者姓名： | 褚朝森 王晓丽 胡玉涛 闫秀美 王政 |
| 基金项目： | 江苏省“青蓝工程”培养基金(2014)和连云港市药物研发共性技术中心科技项目(2013-2015)、江苏省高水平示范性实训基地建设项目专项经费资助(2013-2014) |
| 摘 要： | 建立了溴酸钠和氯化铁为助催化剂2,2,6,6-四甲基-N-氧化哌啶(NaBrO3-FeCl3-TEMPO)新型催化体系,以苯甲醇的氧化为研究对象,得出各成分与底物的最佳物质的量比为:2%TEMPO、35%NaBrO3、3.7%H2SO4、2%FeCl3·6H2O。该体系在室温下可有效实现芳香醇、脂肪醇及杂环醇的氧化,收率高(99%)、选择性强(99%),在无氧条件下,仍表现出较好的催化活性。 |
| 关 键 词： | 四甲基-N-氧化哌啶 溴酸钠 醇 氧化 |
| 收稿时间： | 2014-09-24 |
Catalyzed Oxidation of Alcohols by 2,2,6,6-Tetramethyl-1-iperidinyloxy with Sodium Bromate and Ferric Chloride as Accelorators |
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| CHU Chaosen,WANG Xiaoli,HU Yutao,YAN Xiumei,WANG Zheng. Catalyzed Oxidation of Alcohols by 2,2,6,6-Tetramethyl-1-iperidinyloxy with Sodium Bromate and Ferric Chloride as Accelorators[J]. Chinese Journal of Applied Chemistry, 2015, 32(6): 666-670. DOI: 10.11944/j.issn.1000-0518.2015.06.140331 | |
| Authors: | CHU Chaosen WANG Xiaoli HU Yutao YAN Xiumei WANG Zheng |
| Affiliation: | Lianyungang TCM Branch of Jiangsu Union Technical Institute;Lianyungang Common Technological Center for Drug Research and Development;Jiangsu Deyuan Pharmaceutical Co.,Ltd.,Lianyungang,Jiangsu 222047,China |
| Abstract: | A 2,2,6,6-tetramethyl-1-piperidinyloxy catalytic system with sodium bromate and ferric chloride as accelorators(NaBrO3-FeCl3-TEMPO) was developed for efficient oxidation of alcohols. Taking example for benzyl alcohol, the molar ratios of TEMPO, NaBrO3, H2SO4, FeCl3·6H2O relative to the substrate are optimized at 2%, 35%, 3.7% and 2%, respectively. Aromatic alcohol, aliphatic alcohol and heterocyclic alcohol can be effectively oxidized to the corresponding carbonyl compounds with high yields up to 99% and selectivity up to 99% at room temperature even under anaerobic conditions. |
| Keywords: | tetramethyl-piperidinyloxy sodium bromate alcohol oxidation |
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