Reactivity of nucleosides with a hydroxyl radical in non-aqueous medium |
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| Authors: | Rodríguez-Muñiz Gemma M Marin M Luisa Lhiaubet-Vallet Virginie Miranda Miguel A |
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| Affiliation: | Instituto de Tecnología Química UPV-CSIC, Universidad Politécnica de Valencia, Consejo Superior de Investigaciones Científicas, Avenida de los Naranjos, s/n, 46022 Valencia, Spain. |
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| Abstract: | DNA damage: The reactivity of HO(.) with silylated 2'-deoxyribonucleosides was investigated in acetonitrile by means of a time-resolved technique. The obtained rate constants were in general slightly lower than those reported for the natural nucleosides in water. Analysis of the reaction mixture by UPLC-MS revealed that HO(.) attack occurred at the nucleobase (see scheme). |
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