Novel recognition mechanisms in biological adhesion |
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| Authors: | Deborah Leckband |
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| Affiliation: | 1. Department of Soil Science, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand;2. Institute of Biogeochemistry and Pollutant Dynamics, ETH Zurich, 8092 Zurich, Switzerland;1. Department of Materials Science, Montanuniversität Leoben, Franz-Josef-Strasse 18, 8700 Leoben, Austria;2. Business Unit Electronics, PLANSEE SE, Metallwerk-Plansee-Strasse 71, 6600 Reutte, Austria;3. Erich Schmid Institute of Materials Science, Austrian Academy of Sciences, Jahnstrasse 12, 8700 Leoben, Austria;1. Sustainable Use, Management, and Reclamation of Soil and Water Research Group, Department of Agrarian Science and Technology, Universidad Politécnica de Cartagena, Paseo Alfonso XIII, 52, 30203 Cartagena, Spain;2. Department of Agricultural Chemistry and Soil Science, University of Cordoba, Campus Rabanales, Marie Curie Building, 14071 Cordoba, Spain;1. Soils Department, Federal University of Santa Maria (Universidade Federal de Santa Maria), 97105-900 Santa Maria, RS, Brazil;2. Agronomy Department, University of Santa Catarina State, 88520-000 Lages, SC, Brazil,;3. University of West Santa Catarina, 89620-000 Campos Novos, SC, Brazil;1. Institute of Advanced Materials (INAM), University Jaume I, Avenida de Vicent Sos Baynat, s/n, 12006 Castelló de la Plana, Castellón, Spain;2. Centro de Investigaciones en Catálisis, Universidad Industrial de Santander, C.P.681011, Piedecuesta, Santander, Colombia;3. Centro de Investigación Científica y Tecnológica en Materiales y Nanociencias (CMN), Universidad Industrial de Santander, C.P. 681011 Piedecuesta, Santander, Colombia |
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| Abstract: | ![]()
Molecular recognition is generally thought of in terms of bond formation between unique sites on host and complementary guest molecules, but recent studies have revealed new complexities in biological recognition at cell. Adhesion between cell surfaces similarly involves specific interactions between analogous ligands and receptors. Recent force measurements, however, suggest that cell adhesion proteins may bind via multiple interaction sites that can form in a sequential manner. Other studies further show that in some instances, the principal recognition event may not be receptor–ligand docking, but the assembly of a complex pattern of many receptors and ligands. |
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| Keywords: | Recognition Cell adhesion Force measurements Self-assembly Cadherin Synapse |
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