| Reduced Bone Mineral Density and Bone Metabolism in Aquaporin-1 Knockout Mice |
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| 作者姓名： | WU Qing-tian MA Qing-jie HE Cheng-yan WANG Cai-xia GAO Shi HOU Xia MA Tong-hui |
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| 作者单位： | WU Qing-tian1，3，MA Qing-jie2，HE Cheng-yan2，WANG Cai-xia3，GAO Shi2，HOU Xia1 and MA Tong-hui11. Membrane Channel Research Laboratory，Northeast Normal University，Changchun 130024，P. R. China; 2. China-Japan Union Hospital，Jilin University，Changchun 130033，P. R. China;3. School of Basic Medicine，Jamusi University，Jamusi 154002，P. R. China |
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| 基金项目： | 国家自然科学基金，国家自然科学基金，吉林省杰出青年科学基金，Excellent Young Teachers Program of MOE |
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| 摘 要： | An overt phenotype of aquaporin-1 knockout(AQP1 ko) mice is growth retardation, suggesting possible defects in bone development and metabolism. In the present study, we analyzed the bone mineral density(BMD), bone calcium and phosphorus contents, and bone metabolism in an AQP1 ko mouse model. The BMD of femurs in AQP1 ko mice was significantly lower than that of litter-matched wildtype mice as measured by dual energy X-ray absorptiometry. Consistently, the contents of bone total calcium and phosphorus were also significantly lower in AQP1 ko mice. The reduced BMD caused by AQP1 deficiency mainly affect male mice. Bone metabolic activity, as indicated by 99mTc-MDP absorption measurements, was remarkably reduced in AQP1 ko mice. These results provide the first evidence that AQP1 play an important role in bone structure and metabolism.
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| 关 键 词： | 水通道蛋白-1基因敲除 小白鼠 骨矿物质密度降低 骨骼代谢 |
| 收稿时间： | 31 January 2007 |
| 修稿时间： | 2007-01-31 |
Reduced Bone Mineral Density and Bone Metabolism in Aquaporin-1 Knockout Mice |
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| WU Qing-tian MA Qing-jie HE Cheng-yan WANG Cai-xia GAO Shi HOU Xia MA Tong-hui.Reduced Bone Mineral Density and Bone Metabolism in Aquaporin-1 Knockout Mice[J].Chemical Research in Chinese University,2007,23(3):297-299. |
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| Authors: | Qing-tian WU Qing-jie MA Cheng-yan HE Cai-xia WANG Shi GAO Xia HOU Tong-hui MA |
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| Institution: | aMembrane Channel Research Laboratory, Northeast Normal University, Changchun 130024, P. R. China;bChina-Japan Union Hospital, Jilin University, Changchun 130033, P. R. China;cSchool, of Basic Medicine, Jamusi University, Jamusi 154002, P. R. China |
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| Abstract: | An overt phenotype of aquaporin-1 knockout(AQP1 ko) mice is growth retardation, suggesting possible defects in bone development and metabolism. In the present study, we analyzed the bone mineral density(BMD), bone calcium and phosphorus contents, and bone metabolism in an AQP1 ko mouse model. The BMD of femurs in AQP1 ko mice was significantly lower than that of litter-matched wildtype mice as measured by dual energy X-ray absorptiometry. Consistently, the contents of bone total calcium and phosphorus were also significantly lower in AQP1 ko mice. The reduced BMD caused by AQP1 deficiency mainly affect male mice. Bone metabolic activity, as indicated by 99mTc-MDP absorption measurements, was remarkably reduced in AQP1 ko mice. These results provide the first evidence that AQP1 play an important role in bone structure and metabolism. |
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| Keywords: | Aquaporin Gene knockout Bone mineral density Bone metabolism |
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