| 基于甲磺酰基的磺酰胺-氨醇作为催化醛的不对称炔基化反应新配体 |
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| 引用本文： | 金薇,黄永波,万伯顺.基于甲磺酰基的磺酰胺-氨醇作为催化醛的不对称炔基化反应新配体[J].催化学报,2010,31(9):1098-1102. |
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| 作者姓名： | 金薇 黄永波 万伯顺 |
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| 作者单位： | 中国科学院大连化学物理研究所,辽宁,大连,116023 |
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| 基金项目： | Supported by the National Basic Research Program of China (973 Program,2010CB833300) |
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| 摘 要： | 以商业易得的 (–)-麻黄碱、(+)-伪麻黄碱和各种手性氨醇为主要原料, 经过简单的两步反应, 合成了一系列基于甲磺酰基的磺酰胺-氨醇 (SAA) 配体, 并将其用于催化苯乙炔基锌对醛的不对称加成反应. 在没有 Ti(OiPr)4 等金属试剂的条件下, 配体表现出较好的不对称诱导能力, 取得了高达 83% ee.
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| 关 键 词： | 磺酰胺-氨醇配体 不对称加成 炔基化反应 醛 |
| 收稿时间： | 2010-09-30 |
Methylsulfonyl-Based Sulfamide-Amine Alcohol as a Ligand for Enantioselective Alkynylation of Aldehydes |
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| JIN Wei,HUANG Yongbo,WAN Boshun.Methylsulfonyl-Based Sulfamide-Amine Alcohol as a Ligand for Enantioselective Alkynylation of Aldehydes[J].Chinese Journal of Catalysis,2010,31(9):1098-1102. |
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| Authors: | JIN Wei HUANG Yongbo WAN Boshun |
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| Institution: | Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China |
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| Abstract: | Chiral methylsulfonyl-based sulfamide-amine alcohol (SAA) ligands were synthesized from commercially available starting materials in two simple steps. Methylsulfonyl-based SAA ligands catalyzed the asymmetric alkynylation of various aldehydes using alkynylzinc to provide chiral propargyl alcohols with moderate to good enantioselectivity up to 83% ee. |
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| Keywords: | sulfamide-amine alcohol enantioselective addition alkynylation aldehyde |
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