High-resolution NMR spectroscopy of membrane proteins in aligned bicelles |
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| Authors: | De Angelis Anna A Nevzorov Alexander A Park Sang Ho Howell Stanley C Mrse Anthony A Opella Stanley J |
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| Institution: | Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0307, USA. |
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| Abstract: | High-resolution solid-state NMR spectra can be obtained from uniformly (15)N-labeled membrane proteins in magnetically aligned bicelles. Fast uniaxial diffusion about the axis of the bilayer normal results in single-line spectra that contain the orientational information necessary for protein structure determination. |
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