Structure determination of selaginellins G and H from Selaginella pulvinata by NMR spectroscopy |
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| Authors: | Yuan Cao Ji‐Jun Chen Ning‐Hua Tan Yong‐Ping Wu Jie Yang Qiang Wang |
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| Institution: | 1. Department of Chinese Materia Medica Analysis, China Pharmaceutical University, Nanjing 210009, People's Republic of China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China;3. Jiangsu Provincial Institute of Materia Medica, Nanjing 210009, People's Republic of China |
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| Abstract: | Selaginellins G ( 1 ) and H ( 2 ), two new selaginellin derivatives, were isolated from the whole plant of Selaginella pulvinata. Their structures were elucidated, and complete assignments of the 1H and 13C NMR spectroscopic data were achieved by 1D and 2D NMR experiments (HSQC, HMBC, COSY and ROESY). Compound 1 displayed good antifungal activity against Candida albicans with an IC50 value of 5.3 µg/ml. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | NMR 1H NMR 13C NMR 2D NMR selaginellin G selaginellin H Selaginella pulvinata Selaginellaceae |
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