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Ruthenium-catalyzed selective synthesis of monoalkylated barbituric acids through “borrowing hydrogen” methodology |
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| Authors: | Anggi Eka Putra Yohei Oe Tetsuo Ohta |
| Institution: | 1. Graduate School of Life and Medical Sciences, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe-shi, Kyoto 610-0394, Japan;2. Department of Biomedical Information, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe-shi, Kyoto 610-0394, Japan |
| Abstract: | An environmentally benign alkylation of barbituric acids via “borrowing hydrogen” process with ruthenium catalysis has been established. The corresponding 5-(alkyl)barubituric acids were obtained in good to excellent yields with low catalyst loading. Various substrates including aliphatic alcohols were tolerated in the present catalytic system. A novel method for construction of barbituric acid-fused benzopyrane derivatives was also demonstrated. |
| Keywords: | Barbituric acids Alkylation Alcohol Borrowing hydrogen Ruthenium catalysis |
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