Synthesis of functionalized 3-arylpyridazines via Pd-catalyzed decarboxylative cross-coupling of pyridazine-3-carboxylic acids期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis of functionalized 3-arylpyridazines via Pd-catalyzed decarboxylative cross-coupling of pyridazine-3-carboxylic acids

Authors:	Shengqiang Wang Hongtao Lu Jingya Li Dapeng Zou Yusheng Wu Yangjie Wu

Affiliation:	1. The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, PR China;2. Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, PR China;3. Tetranov Biopharm, LLC., No. 75 Daxue Road, Zhengzhou 450052, PR China;4. Tetranov International, Inc., 100 Jersey Avenue, Suite A340, New Brunswick, NJ 08901, USA

Abstract:	An efficient and general protocol for the decarboxylative cross-coupling of pyridazine-3-carboxylic acids with aryl-bromides has been described. This method provides a new avenue for the synthesis of 3-arylpyridazines via decarboxylative cross-coupling strategy by employing the dual-catalyst system of Pd(PPh₃)₄/Cu₂O in the presence of Li₂CO₃ at 160 °C in DMA.

Keywords:	Palladium catalysis Pyridazine-3-carboxylic acids 3-Arylpyridazines Decarboxylative cross-coupling
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