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Large deviations estimates for the multiscale analysis of heart rate variability
Authors:Patrick Loiseau,Claire Mé  digue,Paulo Gonç  alves,Najmeddine Attia,Sté  phane Seuret,Franç  ois Cottin,Denis Chemla,Michel Sorine,Julien Barral
Affiliation:1. EURECOM, 2229 route des crêtes, BP 193, F-06560 Sophia-Antipolis cedex, France;2. INRIA Paris-Rocquencourt, domaine de Voluceau, BP 105, 78153 Le Chesnay Cedex, France;3. INRIA Rhône-Alpes, Université de Lyon, École Normale Supérieure de Lyon (LIP), 46 allée d’Italie, 69364 Lyon cedex 07, France;4. LAMA, Université Paris-Est, 61 avenue du Général de Gaulle, 94010 Créteil Cedex, France;5. UBIAE, INSERM 902/EA 3872, Genopole Université d’Evry-Val d’Essonne, ZAC du bras de fer, 3 bis impasse C. Colomb, F-91025 Evry Cedex, France;6. Université Paris-Sud, Faculté de Médecine, Equipe d’Accueil EA4046, Kremlin Bicêtre, F-94276, France;g LAGA, Université Paris 13, 99 rue Jean-Baptiste Clément, 93430 Villetaneuse, France
Abstract:
In the realm of multiscale signal analysis, multifractal analysis provides a natural and rich framework to measure the roughness of a time series. As such, it has drawn special attention of both mathematicians and practitioners, and led them to characterize relevant physiological factors impacting the heart rate variability. Notwithstanding these considerable progresses, multifractal analysis almost exclusively developed around the concept of Legendre singularity spectrum, for which efficient and elaborate estimators exist, but which are structurally blind to subtle features like non-concavity or, to a certain extent, non scaling of the distributions. Large deviations theory allows bypassing these limitations but it is only very recently that performing estimators were proposed to reliably compute the corresponding large deviations singularity spectrum. In this article, we illustrate the relevance of this approach, on both theoretical objects and on human heart rate signals from the Physionet public database. As conjectured, we verify that large deviations principles reveal significant information that otherwise remains hidden with classical approaches, and which can be reminiscent of some physiological characteristics. In particular we quantify the presence/absence of scale invariance of RR signals.
Keywords:Heart rate variability   Multiscale analysis   Multifractal analysis   Large deviations
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