A memory of chirality approach to the stereoselective synthesis of 4-hydroxy-alpha-methylprolines |
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| Authors: | Kolaczkowski Lawrence Barnes David M |
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| Affiliation: | Abbott Global Pharmaceutical Research and Development, Process Chemistry, 1401 Sheridan Road, North Chicago, Illinois 60064-6285, USA. larry.kolaczkowski@abbott.com |
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| Abstract: | ![]()
To extend the memory of chirality (MOC) methodology to structurally more diverse compounds, the synthesis of 4-hydroxy-alpha-methylprolines was undertaken. Yield and selectivity were very good, with an unexpected reversal in selectivity observed for the cyclization of one adduct with an unprotected hydroxyl. |
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