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| The effect of aneurismal-wall mechanical properties on patient-specific hemodynamic simulations： two clinical case reports | |
| 基金项目： | supported by the National Natural Science Foundation of China (30772234); Shanghai Municipal Natural Science Foundation (08ZR1401000); Shanghai Leading Academic Discipline Project(B112). |
| 摘 要： | Hemodynamic factors such as the wall shear stress play an important role in the pathogenesis and treatment of cerebral aneurysms. In present study, we apply computational fluid-structure interaction analyses on cerebral aneurysms with two different constitutive relations for aneurismal wall in order to investigate the effect of the aneurismal wall mechanical properties on the simulation results. We carry out these analyses by using two patient-specific models of cerebral aneurysms of different sizes located in different branches of the circle of Willis. The models are constructed from 3D rotational angiography image data and blood flow dynamics is studied under physiologically representative waveform of inflow. From the patient models analyzed in this investigation, we find that the deformations of cerebral aneurysms are very small. But due to the nonlinear character of the Navier-Stokes equations, these small deformations could have significant influences on the flow characteristics. In addition, we find that the aneurismal-wall mechanical properties have great effects on the deformation distribution of the aneurysm, which also affects the wall shear stress distribution and flow patterns. Therefore, how to define a proper constitutive relation for aneurismal wall should be considered carefully in the hemodynamic simulation. |
| 关 键 词： | 血流动力学 动力学模拟 力学性能 脑动脉 病例报告 Stokes方程 临床 流固耦合分析 |
| 收稿时间： | 2009-05-20 |
The effect of aneurismal-wall mechanical properties on patient-specific hemodynamic simulations: two clinical case reports |
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| Jialiang Chen,Shengzhang Wang,Guanghong Ding,Xinjian Yang,Haiyun Li. The effect of aneurismal-wall mechanical properties on patient-specific hemodynamic simulations: two clinical case reports[J]. Acta Mechanica Sinica, 2009, 25(5): 677-688. DOI: 10.1007/s10409-009-0262-6 | |
| Authors: | Jialiang Chen Shengzhang Wang Guanghong Ding Xinjian Yang Haiyun Li |
| Affiliation: | [1]Department of Mechanics and Engineering Science,Fudan University, 200433 Shanghai, China [2]Beijing Institute of Neurosurgery, 100050 Beijing, China [3]Department of Biomedical Engineering,Capital Medical University, 100050 Beijing, China |
| Abstract: | Hemodynamic factors such as the wall shear stress play an important role in the pathogenesis and treatment of cerebral aneurysms. In present study, we apply computational fluid-structure interaction analyses on cerebral aneurysms with two different constitutive relations for aneur-ismal wall in order to investigate the effect of the aneur- ismal wall mechanical properties on the simulation results. We carry out these analyses by using two patient-specific models of cerebral aneurysms of different sizes loca... |
| Keywords: | Intracranial aneurysm Fluid-structure interaction Computational fluid dynamics Hemodynamics |
| 本文献已被 CNKI 维普 SpringerLink 等数据库收录！ | |