Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Ce(SO4)2-SiO2 as a Heterogeneous and Recyclable Catalyst |
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| Authors: | Wen Pei |
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| Affiliation: | College of Chemical Engineering and Materials , Zhejiang University of Technology , Hangzhou, China |
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| Abstract: | ![]()
A simple and efficient synthesis of 3,4-dihydropyrimidinones or thiones is described, using silica-supported ceric sulfate [Ce(SO4)2-SiO2] as a heterogeneous catalyst from an aldehyde, 1,3-dicarbonyl compound, and urea or thiourea at 110 °C under solvent-free conditions. Compared with the classical Biginelli reaction, this new method consistently has better yields, short reaction time, easy separation, and tolerance toward various functional groups. |
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| Keywords: | Biginelli Ce(SO4)2-SiO2 3,4-dihydropyrimidinones solvent-free |
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